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phenobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Lively alkylating metabolites.Phenobarbital is usually a barbituric acid by-product for oral administration and happens to be a white, odorless,